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目的:研究梢地祛银胶囊对银屑病模型的治疗作用及止痒抗炎作用,为临床用于治疗银屑病提供理论依据。方法:以小鼠尾鳞片表皮模型和雌激素期阴道上皮模型,观察梢地祛银胶囊对银屑病模型的治疗作用;以豚鼠磷酸组织胺致痒阈实验、角叉菜致大鼠足跖肿胀实验,观察梢地祛银胶囊对实验性瘙瘁和急性炎症的抑制作用。结果:梢地祛银胶囊能显著促进鼠尾鳞片颗粒层的形成、抑制鼠阴道上皮细胞有丝分裂,提高磷酸组织胺对豚鼠的致痒阈、抑制实验性小鼠急性炎症,差异均有统计学意义(P<0.05)。结论:梢地祛银胶囊可能通过促进颗粒层的形成、抑制表皮细胞增殖与促进其分化、抑制瘙痒和炎症,而发挥治疗银屑病的作用。
OBJECTIVE: To study the therapeutic effect and antipruritic and anti-inflammatory effects of Shidi Quyin Capsule on psoriasis model and provide a theoretical basis for the clinical treatment of psoriasis. Methods: The mice tail scale epidermis model and estrogen vaginal epithelial model was used to observe the therapeutic effect of Toutiji Qiyin Capsule on psoriasis model; histamine induced itch threshold in guinea pigs, carrageenan-induced rat plantar Swollen experiment, observe the Shidi Qu silver capsules on experimental pruritus and acute inflammation inhibition. Results: Shidi Qu cancer capsule can significantly promote the formation of mouse tail scale particle layer, inhibit mouse vaginal epithelial cell mitosis, improve histamine phosphate phosphuric acid itch threshold guinea pigs, inhibit experimental mice acute inflammation, the differences were statistically significant (P <0.05). Conclusion: Shudishuyin Capsule may play a role in the treatment of psoriasis by promoting the formation of granular layer, inhibiting the proliferation and promoting the differentiation of epidermal cells and inhibiting itching and inflammation.