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目的 :探讨氨甲喋呤 (MTX)治疗异位妊娠的效果及监测方法。方法 :采用单次MTX50mg肌肉注射 ,定期作血清β HCG测定和B超检查。结果 :30例患者治疗成功 2 1例 ,占 70 % ,血清β HCG下降大于 15%需要的时间为 (5.0 5± 1.96 )d ,肌注药物 4～ 5d内血清 β HCG下降超过15%者治疗成功机会大。结论 :MTX是治疗异位妊娠的一种有效安全、简单的方法。治疗过程中 ,检测血清 β HCG值 ,作动态观察 ,是判断疗效的重要手段。初测血清β HCG值 (≤ 50 0 0IU/L)及妊娠包块大小 (B超下≤ 6cm)与治疗效果无明显关系。肌注MTX后 4～ 5d时是关键的观察期。
Objective: To investigate the efficacy and monitoring of methotrexate (MTX) in the treatment of ectopic pregnancy. Methods: A single MTX50mg intramuscular injection, regular serum β HCG determination and B-ultrasound. Results: The success rate of 30 patients was 21% (70%), the serum β-HCG decreased more than 15% (5.0 ± 1.96) d, and the serum β-HCG decreased more than 15% 4 ~ 5 days after intramuscular injection Great chance of success. Conclusion: MTX is an effective and safe method for the treatment of ectopic pregnancy. During the course of treatment, the detection of serum β HCG value, for dynamic observation, is an important means to determine the efficacy. The serum beta-HCG (≤50 0 IU / L) and the size of pregnancy mass (≤6 cm) had no significant relationship with the therapeutic effect. MTX 4 ~ 5d after intramuscular injection is the key observation period.