本文报道２０例风湿性二尖瓣关闭不全病人静滴川芎嗪的治疗效果，结果表明静滴川芎嗪后心输出量增高，心肌收缩性能加强，肺瘀血减轻，全血粘度降低，动脉血氧分压增高，临床症状缓解。川芎嗪的临床效果可能与钙通道阻滞活性、降低肺动脉压，减轻外周阻力有关。静滴川芎嗪的良好血流动力学效应，对于术前纠正二尖瓣关闭不全患者的心功能不全有一定的意义。 This article reports 20 cases of rheumatic mitral regurgitation in patients with intravenous infusion of ligustrazine, the results showed that intravenous infusion of ligustrazine increased cardiac output, enhanced myocardial contractility, reduced lung blood stasis, reduced whole blood viscosity, arterial oxygen Increased partial pressure, clinical symptoms relieved. The clinical effect of ligustrazine may be related to calcium channel blockade activity, lowering pulmonary arterial pressure and relieving peripheral resistance. Intravenous tetramethylpyrazine good hemodynamic effect, for preoperative correction of mitral regurgitation in patients with heart failure have some significance.