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目的运用BP神经网络模型,研究芪附汤对心肌缺血再灌注损伤大鼠ST值变化的影响。方法采用BP神经网络拟合心肌缺血再灌注损伤大鼠的ST值,得出大鼠ST值“时-效”曲线。根据“时-效”曲线,求算最大药效值(Emax)和药效峰值时间(Tmax),确立药效时间窗。结果通过对上述各药效参数的求算来综合评价芪附汤对心肌缺血再灌注损伤大鼠ST值变化的影响,客观的反映出芪附汤对心肌缺血再灌注损伤大鼠的时序性与整体性药效作用特点。结论该方法体现了芪附汤对心肌缺血再灌注损伤大鼠的时序性与整体性药效作用特征。
Objective To study the effect of Qifu Tang on the changes of ST level in rats with myocardial ischemia-reperfusion injury using BP neural network model. Methods BP neural network was used to fit the ST value of myocardial ischemia-reperfusion injury in rats, the ST value of “ST-effect” curve was obtained. According to the “time-effect” curve, calculate the maximum effective value (Emax) and pharmacodynamic peak time (Tmax), to establish the efficacy of time window. Results Through the calculation of the above parameters, the effect of Qifu Decoction on the changes of ST value in rats with myocardial ischemia-reperfusion injury was comprehensively evaluated, and the timing of Qifu decoction in rats with myocardial ischemia-reperfusion injury was objectively reflected Sexual and holistic effects. Conclusion This method reflects the timing and overall pharmacodynamic effects of Qifu Tang on myocardial ischemia-reperfusion injury in rats.