论文部分内容阅读
（Ｅ）３〔３（４氟苯基）１（１甲基乙基）１Ｈ吲哚２基〕２丙烯醛（２）是合成氟伐他汀的关键中间体．从苯胺经异丙基化、与２氯１（４氟苯基）乙酮缩合、氯化锌催化的分子内环合、在Ｖｉｌｓｍｅｉｅｒ反应条件下与３（Ｎ甲基Ｎ苯基）丙烯醛反应合成（２），四步反应总收率为５４％．
(E) 3 3 (4 fluorophenyl) 1 (1 methyl ethyl) 1 H indole 2 base 2 acrolein (2) is the synthesis of fluvastatin The key intermediates. From aniline by isopropylation, and 2 chloro 1 (4 fluorophenyl) ethanone condensation, zinc chloride catalytic intramolecular cyclization in the Vilsmeier reaction conditions with 3 (N methyl N phenyl) acrolein synthesis (2), the total yield of four-step reaction was 54%.