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目的:观察手足口病方对新疆地区小儿手足口病的疗效及对Th1/Th2细胞因子的影响。方法:将80例手足口病患儿随机分为手足口病方治疗组和利巴韦林对照组,另选择同期经过体检中心体检的健康小儿20例血清作为正常组,评价治疗前后两组临床疗效,疱疹消退时间和体温恢复正常时间,检测治疗前后患儿Th1/Th2细胞因子γ干扰素(IFN-γ)、白介素-2(IL-2)、白介素-6(IL-6)和白介素-10(IL-10)水平。结果:治疗组痊愈率和总有效率显著高于对照组;治疗组疱疹消退时间和体温恢复正常时间较对照组明显缩短;两组患儿治疗前Th1/Th2细胞因子IFN-γ、IL-2、IL-6、IL-10较正常组明显升高,两组治疗后Th1/Th2细胞因子IFN-γ、IL-2、IL-6、IL-10均较治疗前明显降低,治疗组较对照组恢复更快,治疗组接近正常组,对照组仍高于正常组。结论:手足口病方治疗新疆地区小儿手足口病临床疗效显著,可以调节Th1/Th2细胞因子水平,改善患儿的免疫功能。
Objective: To observe the curative effect of hand, foot and mouth disease on children hand-foot-mouth disease in Xinjiang and its effect on Th1 / Th2 cytokines. Methods: Eighty children with HFMD were randomly divided into treatment group (HFMD group) and ribavirin control group. 20 healthy children with the same physical examination at the same period were selected as normal group, Efficacy, Herpes remission time and body temperature returned to normal time before and after treatment, the detection of Th1 / Th2 cytokines IFN-γ, IL-2, IL-6 and interleukin- 10 (IL-10) levels. Results: The cure rate and total effective rate in the treatment group were significantly higher than those in the control group. The hernia subsided time and body temperature returned to normal in the treatment group were significantly shorter than those in the control group. The levels of Th1 / Th2 cytokines IFN-γ, IL-2 , IL-6 and IL-10 were significantly higher than those in the normal group. The levels of Th1 / Th2 cytokines IFN-γ, IL-2, IL-6 and IL-10 in both groups were significantly lower than those before treatment Group recovery faster, the treatment group close to the normal group, the control group is still higher than the normal group. Conclusion: The therapeutic effect of hand, foot and mouth disease in children with HFMD in Xinjiang is significant. It can regulate the level of Th1 / Th2 cytokines and improve the immune function in children.