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为早期判断新生儿缺氧缺血性脑病（ＨＩＥ）预后，将５９例足月ＨＩＥ新生儿在生后一周内采用临床分度法、ＣＴ分度法、新生儿行为神经测定（ＮＢＮＡ）以及检测生后第３天血清神经元特异性烯醇酶（ＮＳＥ）和血浆内皮素－１（ＥＴ－１）浓度５种方法进行预后评估，并于生后３个月、６个月时作神经发育随访，结果临床分度法、ＣＴ分度法、ＮＢＮＡ、血清ＮＳＥ及血浆ＥＴ－１浓度检测法预测ＨＩＥ预后的敏感性分别为１００％、１００％、８５％、８５％和８５．７１％，特异性分别为５１．５２％、４７．６２％、６６．６７％、９０．９１％和７１．８８％，提示血清ＮＳＥ检测法预测预后价值最高，为ＨＩＥ预后早期评估提供客观而比较可靠的方法
To determine the prognosis of neonatal hypoxic-ischemic encephalopathy (HIE) early, 59 full-term neonates with HIE were enrolled in this study. Clinical index, CT score, neonatal behavioral nerve assay (NBNA) Five neuroprogenitors (NSE) and plasma endothelin-1 (ET-1) concentrations were evaluated on the third day after birth to assess the prognosis. Neurological development was performed at 3 and 6 months after birth The follow-up results showed that the sensitivity of predicting the prognosis of HIE with clinical index, CT index, NBNA, serum NSE and plasma ET-1 concentration were 100%, 100%, 85%, 85% and 85.71% The specificity was 51.52%, 47.62%, 66.67%, 90.91% and 71.88% respectively, suggesting that the serum NSE test predicts the highest prognosis value and provides an objective and reliable test for the early assessment of HIE prognosis method