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目的探讨中国急性冠脉征接受介入治疗患者中慢性肾脏病的患病率及危险因素。方法对于全国20个中心的1854例在2007年2月1日以前接受介入治疗的急性冠脉综合征患者进行病史采集、肾脏损伤指标及相关危险因素的检测。结果在1793例资料完整的患者中,白蛋白尿的患病率为10.6%,肾功能下降的患病率为10.0%,血尿或非感染性白细胞尿的患病率为7.1%。在急性冠脉综合征接受介入治疗的患者中慢性肾脏病的患病率为22.8%,知晓率为11.3%。多因素logistic回归提示,性别、既往慢性肾脏病病史、高血压、糖尿病、贫血、高尿酸血症、尿蛋白阳性以及年龄每增加10岁均是肾小球滤过率(eGFR)低于60ml.min-1.1.73m-2的危险因素。结论慢性肾脏病在急性冠脉综合征接受介入治疗的患者中患病率高,但临床中自我知晓率明显偏低,对所有因急性冠脉综合征而住院的患者尤其那些合并相关危险因素的患者应进行eGFR估算。
Objective To investigate the prevalence and risk factors of chronic kidney disease in Chinese patients undergoing coronary intervention. Methods A total of 1854 patients with acute coronary syndrome who underwent PCI before February 1, 2007 in 20 centers in China were enrolled in the study. Their medical history, indexes of kidney injury and related risk factors were detected. Results Among 1793 patients with complete data, the prevalence of albuminuria was 10.6%, the prevalence of decreased renal function was 10.0%, and the prevalence of hematuria or non-infectious leucocytosis was 7.1%. The prevalence of chronic kidney disease was 22.8% in patients who received interventional therapy for acute coronary syndromes, with an awareness rate of 11.3%. Multivariate logistic regression showed that glomerular filtration rate (eGFR) was less than 60 ml for each 10-year-old age, gender, history of previous chronic kidney disease, hypertension, diabetes mellitus, anemia, hyperuricemia, urinary protein positive. min-1.1.73m-2 risk factors. Conclusions Chronic kidney disease has a high prevalence in patients undergoing PCI with acute coronary syndrome. However, the self-awareness rate in clinical patients is significantly lower. All patients hospitalized with acute coronary syndromes, especially those with associated risk factors Patients should be eGFR estimates.