论文部分内容阅读
回顾第一个组织特异性的血管生成因子:内分泌腺源性血管内皮生长因子(endocrine glands-derived-vascu lar endothelial growth factor,EG-VEGF)的研究与进展,发现EG-VEGF仅对有内分泌因素存在的靶器官、靶细胞产生作用,这些作用是通过与G-蛋白偶联受体结合激活蛋白激酶p44/42和磷脂酰肌醇3-激酶信号通路来发挥功能,以促进肿瘤血管形成、细胞扩增和转移。以EG-VEGF为靶位点的治疗方法可能为肿瘤治疗提供一个新的途径。
Review of the first tissue-specific angiogenic factor: endocrine glands-derived-vascu lar endothelial growth factor (EG-VEGF) research and progress, found that EG-VEGF only has endocrine factors Existing target organs and target cells produce effects that function by binding to G-protein-coupled receptors to activate protein kinases p44/42 and phosphatidylinositol 3-kinase signaling pathways to promote tumor angiogenesis and cells Amplification and transfer. Treatments targeting EG-VEGF may provide a new approach to cancer treatment.