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为探讨术前判定喉癌颈淋巴结转移的简便血清学方法,采用单克隆抗体—放射免疫分析法对57例声门上型喉癌术前血清癌胚抗原(CEA)含量进行了测定。结果表明,>5ng/ml 者,颈淋巴结转移组的阳性概率为39.3%(11/28),显著高于非转移组的概率20.7%(6/29),差异有显著意义(P<0.05)。以>5.0ng/ml为预测指标,灵敏度为39%,特异度为79%。结论:术前测定血清 CEA 含量,对判定颈淋巴结转移有一定参考价值。
In order to investigate the simple serological method for preoperative determination of cervical lymph node metastasis of laryngeal carcinoma, the serum CEA levels in 57 cases of supraglottic laryngeal carcinoma were determined by monoclonal antibody-radioimmunoassay. The results showed that the positive rate of cervical lymph node metastasis was 39.3% (11/28) in patients with> 5ng / ml, which was significantly higher than that in non-metastatic patients (20.7%, 6/29) (P <0.05) . With> 5.0ng / ml as a predictor, the sensitivity was 39% and the specificity was 79%. Conclusion: Preoperative determination of serum CEA levels for the determination of cervical lymph node metastasis has some reference value.