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胃肠道癌的治疗目前仍以手术切除为主,但晚期不能手术者,化疗仍是主要治疗手段。化疗方案很多,但疗效不理想,自1996年6月起,我们应用大剂量醛氢叶酸(HDCF)、5-Fu、DDP 联合方案(简称 HDCF/5-Fu+DDP)治疗晚期胃肠道癌138例。疗效满意。现将结果报告如下:1 资料与方法1.1 病例资料例晚期胃肠道癌均经病理或细胞学证实,其中胃癌56例,结直肠癌82例。男性109例,女性29例,年龄23～72岁(中位年龄53岁),KPS 评分60分以上。138例病人均有可测量的肿瘤病变,其中肺转移18例,肝转移72例,锁骨上淋巴结转移18例,腹腔肿块23例,盆腔病变7例。
The treatment of gastrointestinal cancer is still based on surgical resection. However, in patients who cannot undergo surgery at the late stage, chemotherapy is still the main treatment. There are many chemotherapy regimens, but the efficacy is not satisfactory. Since June 1996, we have used high doses of the combination of HDCF, 5-Fu, and DDP (abbreviated as HDCF/5-Fu+DDP) to treat advanced gastrointestinal cancer. 138 cases. Satisfactory results. The results are reported as follows: 1 Materials and Methods 1.1 Cases of patients with advanced gastrointestinal cancer were confirmed by pathology or cytology, including 56 cases of gastric cancer, 82 cases of colorectal cancer. There were 109 males and 29 females, aged 23-72 years (median age 53 years), and a KPS score of 60 or more. All 138 patients had measurable tumor lesions, including 18 cases of lung metastases, 72 cases of hepatic metastases, 18 cases of supraclavicular lymph node metastases, 23 cases of abdominal masses, and 7 cases of pelvic lesions.