冷冻技术在泌尿外科中的应用已有60多年的历史,早在19世纪初期De Quervain就试用二氧化碳雪治疗膀胱肿瘤,但当时由于缺乏对冷冻生物学特性的了解以及致冷剂和冷冻器械等的限制,因此未能引起人们的重视。迨至1961年Cooper、Krwawicz相继应用液氮治疗巴金森氏病和白内障取得可喜成绩之后,冷冻疗法便仅快获得了广泛应用。1964年Gonder等首先报告冷冻摧毁前列 Frozen technology has been used in urology for more than 60 years. De Quervain tried to treat bladder cancer as early as the early 19th century because of the lack of understanding of the biological characteristics of freezing and the use of refrigerants and freezers Restrictions, it failed to arouse people’s attention.迨 Until 1961, Cooper, Krwawicz have applied liquid nitrogen to treat Parkinson’s disease and cataracts to obtain gratifying results, the cryotherapy has been rapidly gaining wide application. In 1964 Gonder et al. First reported that freezing destroyed the forefront