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目的:探讨使用地佐辛进行超前镇痛对经腹宫颈癌根治手术患者的临床价值。方法:选取50例择期全麻下行经腹宫颈癌根治术患者,随机分为C、D两组:D组(地佐辛组)于麻醉诱导前20min静脉给予地佐辛(5mL生理盐水中含有地佐辛5mg),C组(控制组)于麻醉诱导前20min静脉直接给予生理盐水5mL;术后患者均给予舒芬太尼静脉自控镇痛泵自主镇痛。各组患者于注射地佐辛(或生理盐水)前(T1)、术后4h(T2)及12h(T3)各时间段抽血进行皮质醇(Cor)、促肾上腺皮质激素(ACTH)和C反应蛋白(CRP)的含量分析。记录患者于经腹宫颈癌根治术后4、8、12、24h的VAS评分。结果:两组在T1和T2时的血浆Cor、ACTH浓度及血清CRP浓度较T3时相比明显升高;而与C组相比,D组在T1和T2时血浆Cor、ACTH浓度及血清CRP浓度均明显降低。术后4、8、12hD组的VAS评分较C组下降;与C组相比,D组术后8、12、24h患者自控镇痛总次数及有效次数减少。结论:使用地佐辛超前镇痛能有效减轻经腹宫颈癌根治术患者的术后应激反应、缓解患者疼痛。
Objective: To investigate the clinical value of dezocine for advanced analgesia in patients undergoing radical surgery for transabdominal cervical cancer. Methods: Fifty patients undergoing radical gastrectomy for cervical cancer undergoing elective general anesthesia were randomly divided into two groups: group D (dezocine) given intravenously to dezocine 20 min before induction of anesthesia (5 mL saline Dezocine 5mg). Group C (control group) received intravenous 5mL normal saline 20min before induction of anesthesia. All patients were given sufentanil intravenous controlled analgesia pump for analgesia. The patients in each group were given blood before and after dezocine injection (T1), 4h (T2) and 12h (T3) respectively. The levels of Cortisol (COR), adrenocorticotropic hormone (ACTH) Reactive protein (CRP) content analysis. The VAS scores were recorded at 4, 8, 12 and 24 h after radical cesarean cervical cancer. Results: The levels of plasma Cor, ACTH and serum CRP concentrations at T1 and T2 were significantly increased in both groups compared with those at T3, while the levels of Cor and ACTH in serum and serum CRP The concentration was significantly reduced. The VAS score of 4, 8 and 12 h after operation decreased compared with that of C group. Compared with C group, the total number of analgesia and the number of effective analgesia in D group decreased at 8, 12 and 24 hours after operation. Conclusion: The preoperative dezocine analgesia can effectively relieve the postoperative stress response in patients undergoing radical cervical cancer radical operation and relieve the pain in patients.