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四乙铵(tetraethylammonium)和河豚毒素(tetrodotoxin)可以分别使神经元细胞钾离子和钠离子通道中毒,从而导致电导降低和有效通道数减少.数值模拟研究了钾离子和钠离子通道中毒对耦合Hodgkin-Huxley神经元集体激发(collective spiking)行为的影响.发现对于一定数目的神经元,随离子通道簇面积(patchsize)的变化,离子通道中毒既可以增强也可以降低集体激发的规则性(regularity);当簇面积大小固定时,对于较小和较大的簇面积,钾离子和钠离子通道中毒可以分别降低和增强集体激发的规则性,但二者变化的簇面积范围不同.对于某个簇面积,二者的效果可能相反.这一结果与离子通道中毒对单个神经元膜电势激发的影响不同,反映了神经元耦合作用、离子通道中毒导致的电导降低和离子通道噪声增强三者间的相互作用和影响.
Tetraethylammonium and tetrodotoxin poisoned potassium and sodium channels in neuronal cells, respectively, resulting in decreased conductance and decreased number of effective channels. Numerical simulations were performed to investigate the effects of potassium ion and sodium ion channel poisoning on coupled Hodgkin -Huxley Neuronal collective spiking behavior It has been found that for a given number of neurons ion channel poisoning can both increase and decrease the regularity of collective excitation as a function of the patch size of ion channels ; When the size of cluster area is fixed, the potassium ion and sodium ion channel poisoning can reduce and enhance the regularity of collective excitation, respectively, for small and large cluster area, but the range of cluster area varies from one cluster to another Area, the effect of the two may be the opposite .This result and ion channel poisoning on a single neuron membrane potential excitation different, reflecting the neuronal coupling, ion channel poisoning caused by the reduction of conductance and ion channel noise enhancement between the three Interaction and influence.