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1.神经病理性疼痛的治疗现状神经病理性疼痛是严重影响人类生活质量的一种慢性疾病,然而当前针对神经病理性疼痛的治疗效果依然不尽如人意。因此,针对神经病理性疼痛新的治疗策略的研究是当前的重中之重。2.内源性大麻素系统内源性大麻素系统在疼痛调控中起着关键作用。它是由大麻素受体、相应的内源性配体以及与之相关的酶组成。目前已发现2种大麻素受体,它们分别是大麻素受体1(CB1R)和大麻素受体2
1. Therapeutic status of neuropathic pain Neuropathic pain is a chronic disease that seriously affects the quality of human life. However, the current therapeutic effect on neuropathic pain remains unsatisfactory. Therefore, research into new therapeutic strategies for neuropathic pain is currently the top priority. Endocannabinoid system The endocannabinoid system plays a key role in the regulation of pain. It is composed of cannabinoid receptors, the corresponding endogenous ligands and their associated enzymes. Two cannabinoid receptors have now been found, which are cannabinoid receptor 1 (CB1R) and cannabinoid receptor 2