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许多慢性特发性血小板减少性紫癜(ITP)患者对药物或脾切除治疗无效,容易发生出血。作者回顾性分析了1982～1989年诊治的慢性 ITP 成人患者,以明确本病并发严重出血的危险性和危险因素。病人和方法 117例慢性 ITP 患者,诊断时的平均年龄43(16～84)岁,男30、女87例,平均血小板计数49×10~9/L,血红蛋白和白细胞均在正常范围。严重出血指出血过多需要住院或/和出血致血红蛋白至少下降20g/L.诊断时8例患者有严重出血。49例患者未治;68例接受强的松等药治疗,其中33例未达持久完全缓解(CR,持
Many patients with idiopathic thrombocytopenic purpura (ITP) are ineffective with drugs or splenectomy and are prone to bleeding. The authors retrospectively analyzed adult patients with chronic ITP diagnosed and treated from 1982 to 1989 to determine the risk and risk factors for severe bleeding complicated by this disease. Patients and Methods 117 patients with chronic ITP had an average age of 43 (16-84) years at diagnosis, 87 males and 87 females with an average platelet count of 49 × 10-9 / L and hemoglobin and leukocytes in the normal range. Severe haemorrhage Pointed out that excessive bleeding requires hospitalization or / and bleeding caused by hemoglobin decreased at least 20g / L. 8 cases of patients diagnosed with severe bleeding. 49 cases were not cured; 68 cases received prednisone and other drugs, of which 33 cases did not achieve long-term complete remission (CR,