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目的:探讨幽门螺杆菌(Helicobacter pylori,Hp)感染与胃癌的关系。方法:纳入22篇关于Hp感染与胃癌关系的文献,应用Review Manager4.2软件进行Meta分析,计算合并优势比(odd ratio,OR)及OR值95%可信区间(confidence interval,CI),倒漏斗图法定性评价发表性偏倚。结果:Meta分析得出Hp感染与胃癌发病合并OR值为2.47(95%CI为1.74～3.52,χ2=144.18,P<0.01)。本研究倒漏斗分析图形不对称,但经敏感性分析和计算失安全系数证明发表性偏倚的影响较小。结论:Hp感染是胃癌发生的危险因素。
Objective: To investigate the relationship between Helicobacter pylori (Hp) infection and gastric cancer. Methods: Forty-two articles about the relationship between Hp infection and gastric cancer were included in this study. Meta-analysis was performed with Review Manager 4.2 software to calculate the odds ratio (OR) and the 95% confidence interval (CI) Funnel chart qualitative evaluation publication bias. Results: Meta analysis showed that the OR of Hp infection and gastric cancer was 2.47 (95% CI 1.74-3.52, X2 = 144.18, P <0.01). The study inverted funnel analysis of graphic asymmetry, but the sensitivity analysis and calculation of safety factor to prove the impact of published bias less. Conclusion: Hp infection is a risk factor for gastric cancer.