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目的探讨多粘菌素E雾化吸入治疗泛耐药铜绿假单胞菌肺炎的临床疗效及不良反应。方法对呼吸科2006年1月~2008年12月收治的13例泛耐药铜绿假单胞菌性肺炎患者予以加用多粘菌素E雾化吸入治疗,根据临床症状和体征,实验室检查等判定患者的疗效及不良反应。结果经多粘菌素E雾化吸入辅以其他综合治疗有效率达69.2%,其中痊愈5例(38.5%),显效4例(30.7%)。未发生不能耐受的毒副反应。结论多粘菌素E雾化能有效治疗泛耐药铜绿假单胞菌性肺炎,无明显毒副作用。
Objective To investigate the clinical efficacy and adverse reactions of polymyxin E nebulization in the treatment of pan-resistant Pseudomonas aeruginosa pneumonia. Methods Thirteen patients with pan-resistant pseudomonas aeruginosa pneumonia admitted from January 2006 to December 2008 in Respiratory Department were treated with polymyxin E atomization inhalation. According to clinical symptoms and signs, laboratory tests To determine the efficacy of patients and adverse reactions. RESULTS: The effective rate of polymyxin E inhalation combined with other comprehensive treatment was 69.2%, of which 5 cases were cured (38.5%) and 4 cases (30.7%) were cured. No unacceptable side effects occurred. Conclusion Polymyxin E nebulization can effectively treat pan-resistant Pseudomonas aeruginosa pneumonia with no obvious side effects.