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抗原的免疫原性不仅与抗原的分子结构大小、亲水性强弱有关 ,而且与免疫动物的种类、年龄、性别及免疫程序 ,以及抗原和载体蛋白的偶联率大小也有关。ＳＯ3是我们从中国南海线纹芋螺中发现的新的芋螺毒素[1 ] ,具有强烈的镇痛活性 ,目前已进入临床前动物实验。我们通过肽合成法
The antigenic immunogenicity is not only related to the molecular structure size and hydrophilicity of the antigen, but also relates to the type, age, sex and immune process of the immunized animal and the coupling rate of the antigen and the carrier protein. SO3 is a new conotoxin discovered in Conus japonicus from the South China Sea. It has strong analgesic activity and has been tested in preclinical animals. We pass the peptide synthesis method