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目的:对血清sTREM-1、IL-16、TNF-α水平与小儿阑尾炎及治疗效果的相关性进行临床分析。方法:选择2012年1月至2015年1月我院就诊的110例小儿阑尾炎患者为研究组,同时选择同期入我院检查的健康者110例为健康组,并观察血清sTREM-1、IL-16、TNF-α水平与小儿阑尾炎的相关性,同时对研究组进行腹腔镜微创技术切除阑尾,并观察术后患者血清sTREM-1、IL-16、TNF-α水平的变化情况。结果:研究组在治疗前血清sTREM-1、IL-16、TNF-α水平较健康组显著性的增高(P<0.05);研究组在治疗后血清sTREM-1、IL-16、TNF-α水平较健康组无显著性的差异(P>0.05)且较治疗前显著性的降低(P<0.05)。结论:血清sTREM-1、IL-16、TNF-α在阑尾炎时显著性的高于健康组,可以联合作为该疾病的辅助诊断标准,经治疗后其均显著性的降低,亦可以作为该疾病治疗效果的评估指标。
OBJECTIVE: To analyze the correlation between serum sTREM-1, IL-16 and TNF-α levels and pediatric appendicitis and their therapeutic effects. Methods: A total of 110 children with appendicitis in our hospital from January 2012 to January 2015 were selected as the study group, and 110 healthy subjects were enrolled in our hospital during the same period. The serum sTREM-1, IL- 16 and TNF-α levels in children with appendicitis. At the same time, the study group was treated with laparoscopic minimally invasive technique to remove the appendix. The changes of serum sTREM-1, IL-16 and TNF-α levels were observed. Results: The levels of serum sTREM-1, IL-16 and TNF-α in the study group before treatment were significantly higher than those in the healthy group (P <0.05) There was no significant difference between the two groups (P> 0.05) and the level was significantly lower than that before treatment (P <0.05). Conclusions: Serum levels of sTREM-1, IL-16 and TNF-α in appendicitis were significantly higher than those in healthy group, which could be used as auxiliary diagnostic criteria for this disease. After treatment, they were all significantly reduced and could be used as the disease Evaluation of the therapeutic effect.