195 8年 ,A.L erner等从猪松果体提取液中分离出一种能使青蛙皮肤褪色物质 ,其化学结构为 N-乙酰 - 5 -甲氧基色胺 ,称之为褪黑素 (melatonin,M)。褪黑素参与调节人体生物节律、性成熟和睡眠及具有抗氧化、免疫调控等多方面功能。近年来发现褪黑素在胃肠道中广泛存在 ,对胃肠道 In 1958, AL erner et al. Isolated from the extract of the pineal gland, a compound that renders the frog skin fading. Its chemical structure is N-acetyl-5-methoxytryptamine, termed melatonin M). Melatonin is involved in the regulation of human biological rhythms, sexual maturity and sleep, and has various functions such as anti-oxidant and immune regulation. In recent years, melatonin found in the gastrointestinal tract widespread in the gastrointestinal tract