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观察人胃癌原位移植至裸小鼠体内后的浸润转移特征，并探讨其发生机制。ＢＡＬＢ／Ｃ－ｎｕ／ｎｕ裸小鼠１２只，以ＳＧＣ－７９０１人胃癌细胞株裸鼠皮下移植瘤为材料，通过手术将瘤组织块移植到裸小鼠胃壁，待动物濒临死亡时进行系统解剖，观察其浸润转移的部位及特征。原位移植瘤全部成功，且所有动物均出现局部浸润及淋巴结转移，肝脏转移率为６６．７％，癌性腹水的发生率为５０％。移植肿瘤晚期还可向脾脏、胰腺及肾脏等处浸润转移，荷瘤鼠最后死于全身衰竭。人胃癌原位移植到裸小鼠体内后，可发生与临床胃癌类似的浸润转移特性
Observe the characteristics of invasion and metastasis of human gastric cancer after orthotopic transplantation in nude mice, and explore its mechanism. Twelve BALB/C-nu/nu-nude mice were transplanted with SGC-7901 human gastric cancer cell line subcutaneously in nude mice. The tumor tissue blocks were transplanted to the stomach wall of nude mice by surgery, and the system was dissected when the animals died on the verge of death. Observe the sites and characteristics of infiltration and metastasis. All orthotopic transplanted tumors were successful, and all animals showed local infiltration and lymph node metastasis. The liver metastasis rate was 66.7%, and the incidence of cancerous ascites was 50%. In the late stages of transplanted tumors, infiltration and metastasis can also occur in the spleen, pancreas, and kidneys, and the tumor-bearing mice eventually die of systemic failure. After human orthotopic transplantation of human gastric cancer into nude mice, invasive and metastatic characteristics similar to those of clinical gastric cancer can occur