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目的探讨甲硝唑联合乳酸杆菌应用于妊娠期滴虫性阴道炎临床治疗中的效果。方法 110例妊娠期滴虫性阴道炎患者,随机分为研究组和对照组,每组55例。对照组仅给予甲硝唑进行治疗,研究组采用小剂量甲硝唑联合乳酸杆菌进行治疗。比较两组患者临床疗效及复发情况,并记录两组患者经用药治疗后不良反应发生情况,以评估用药安全性。结果研究组治疗总有效率为96.36%,对照组治疗总有效率为80.00%,研究组治疗总有效率明显优于对照组(P<0.05)。研究组加用乳酸杆菌后,不良发应发生率为5.45%,与对照组的7.27%比较,差异无统计学意义(P>0.05)。出院后随访6个月,研究组患者中未出现复发病例,对照组复发率为12.73%,差异具有统计学意义(P<0.05)。结论甲硝唑联合乳酸杆菌应用于妊娠期滴虫性阴道炎临床治疗中,可有效提高临床疗效,降低复发率,用药安全性高,值得临床推广应用。
Objective To investigate the effect of metronidazole combined with lactobacillus in the clinical treatment of gestational trichomonas vaginitis. Methods 110 cases of gestational trichomonas vaginitis patients were randomly divided into study group and control group, 55 cases in each group. The control group was treated with metronidazole only, and the study group was treated with metronidazole and lactobacillus. The clinical efficacy and recurrence of the two groups were compared, and the incidence of adverse reactions in the two groups were recorded to evaluate the safety of the medication. Results The total effective rate was 96.36% in the study group and 80.00% in the control group. The total effective rate of the study group was significantly better than that of the control group (P <0.05). Addition of Lactobacillus to study group, the incidence of adverse reactions was 5.45%, compared with 7.27% in the control group, the difference was not statistically significant (P> 0.05). The patients were followed up for 6 months after discharge. There was no recurrence in the study group. The recurrence rate in the control group was 12.73%. The difference was statistically significant (P <0.05). Conclusion Metronidazole combined with Lactobacillus in the clinical treatment of trichomonas vaginitis in pregnancy, which can effectively improve the clinical efficacy, reduce the recurrence rate, high drug safety, it is worthy of clinical promotion and application.