论文部分内容阅读
本文对小鼠腹腔多房棘球蚴(泡球蚴)早期和晚期感染分别进行丙硫咪唑和中药消包粉的实验治疗,药物分为单用西药、单用中药和中西药并用三组,均采用药饵口饲法,考核药效依据主要是小鼠腹腔泡球蚴湿重均值和抑制率、泡球蚴病理分级率和超微结构等,然后进行t检验和X~2检验,计算P值。三组治疗早期感染小鼠均有阻抑泡球蚴增殖生长之效(P<0.01),中药消包粉虽显抗泡球蚴的作用,但其药效不及丙硫咪唑,中西药并用亦未明显起到中药增强西药之效,然超微结构所见却显较重的损害程度。三组治疗晚期感染小鼠的腹腔泡球蚴抑制率,经t检验无显著差异(P>0.05),表明三组之间无阻抑泡球蚴增长之差别。泡球蚴病理分级率按早期和晚期感染小鼠的药效考核,虽均为单用西药组>中西药并用组>单用中药组,但经x~2检验均无显著差异(P>0.05),提示病理分级率用以考核药效尚待继续研讨。
In this paper, experimental treatment of albendazole and traditional Chinese medicine vanilloid in early and late stage infections of mouse abdominal celiac multilocularis (Echinococcus multilocularis) were divided into three groups: western medicine alone, Baitou gavage method are used, the assessment of drug efficacy is mainly based on the average weight and inhibition rate of mouse peritoneal AEC, pathological grade and ultrastructure of metacercariae, then t test and X ~ 2 test, calculate P value. The three groups of mice in early treatment inhibited the proliferation and growth of Echinococcus granulosus (P <0.01). Although the effect of anti-Echinococcus granulosus was not obvious, Did not significantly play a traditional Chinese medicine to enhance the effectiveness of Western medicine, but the ultrastructure showed significant levels of damage. The inhibitory rates of peritoneal larvae in three groups were no significant difference (P> 0.05) by t test, which showed that there was no difference between the three groups in preventing the growth of metacercariae. Pathological grade of Echinococcus granulosus according to early and late infection in mice efficacy evaluation, although both Western medicine group> Western medicine group> single Chinese medicine group, but by x ~ 2 test were no significant difference (P> 0.05 ), Suggesting that the pathological grading rate to assess the efficacy remains to be discussed.