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目的探讨血浆胰高血糖素(CLU)、内皮素(ET)水平和肝硬化食管静脉曲张出血之间的相关性。方法选取60例肝硬化患者,并选30例健康体检正常人作为对照组。分析血浆胰高血糖素、ET水平与肝硬化门静脉高压性出血、肝功能Child-Pugh分级、肝静脉压力梯度(HVPG)和内镜下“红色征”的关系。结果肝硬化出血组血浆胰高血糖素、ET和HVPG分别为(157.53±10.19)、(89.63±11.40)ng/L、(14.4±2.3),均显著高于肝硬化非出血组(P<0.05);Child-Pugh C级血浆胰高血糖素、ET水平分别为(162.31±9.25)、(96.39±12.03)ng/L,显著高于A级和B级(P<0.05);肝硬化有“红色征”患者的血浆胰高血糖素、ET水平分别为(155.33±13.26)、(93.43±12.94)ng/L,均显著高于无“红色征”组(P<0.05)。结论血浆胰高血糖素、ET水平可为肝硬化门静脉高压相关并发症的预防和治疗提供帮助。
Objective To investigate the relationship between plasma glucagon (CLU), endothelin (ET) level and hepatic cirrhosis and esophageal variceal bleeding. Methods Sixty patients with cirrhosis were selected and 30 healthy people were selected as the control group. The relationship between plasma glucagon and endothelin levels and portal hypertensive cirrhosis, Child-Pugh classification of liver function, hepatic venous pressure gradient (HVPG) and endoscopic red sign were analyzed. Results The levels of plasma glucagon, ET and HVPG were (157.53 ± 10.19) and (89.63 ± 11.40) ng / L and (14.4 ± 2.3), respectively, in cirrhotic patients with liver cirrhosis (all P <0.05) ); Child-Pugh C-level plasma glucagon and ET levels were (162.31 ± 9.25) and (96.39 ± 12.03) ng / L respectively, which were significantly higher than those of A and B The levels of plasma glucagon and ET in patients with “red sign” were (155.33 ± 13.26) and (93.43 ± 12.94) ng / L, respectively, which were significantly higher than those without “red sign” (P <0.05). Conclusions Plasma glucagon and ET levels may be helpful in the prevention and treatment of complications related to portal hypertension in cirrhotic patients.