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目的:了解我院ADR的发生情况,建立与患者用药安全相关的处方管控机制,为患者合理、安全用药提供参考。方法:通过医院信息系统(HIS)收集我院2009-2010年发生的ADR报告297例,分别从年龄与性别构成、ADR严重程度、Naranjo score评分、处理方式、药品种类、ADR累及的器官或系统等进行分析。结果:257例可评估的ADR报告中,男、女比例为0.71:1,其中31～40岁患者发生ADR比例较高,占22.96%。对ADR进行Naranjo score评分,其中1～4分为可能,占88.33%;其次为5～8分为极有可能,占10.51%。对ADR进行严重成度划分,其中轻度占97.67%,中度占2.33%。ADR以药师上报居多,占56.42%。抗菌药物引发ADR位居我院首位,占27.24%;其次引发ADR较多的为诊断试剂,占18.68%。ADR主要累及皮肤及其附件,有124例(占48.25%),其次为消化系统和中枢神经系统。我院HIS中不仅将评估过的ADR反馈给上报人员并将其记载于患者的病历首页。结论:我院ADR通过自动警示预防系统在再次开处方时可起到警示作用,不但保障了患者安全、合理、有效的用药,且避免了ADR的再次发生。
OBJECTIVE: To understand the occurrence of ADR in our hospital and to establish a prescription control mechanism related to the safety of patients ’medication so as to provide a reference for patients’ reasonable and safe medication. METHODS: A total of 297 ADR cases from 2009 to 2010 in our hospital were collected from the hospital information system (HIS). The data included age and sex, ADR severity, Naranjo score, treatment method, drug category, organ or system involved in ADR Analysis. Results: Among the 257 evaluable ADRs, the male-female ratio was 0.71: 1, of which 31 to 40 years old had a higher proportion of ADR, accounting for 22.96%. ADR Naranjo score score, of which 1 to 4 is possible, accounting for 88.33%; followed by 5 to 8 is very likely, accounting for 10.51%. ADR serious degree of division, which accounted for 97.67% mild, moderate 2.33%. ADR reported to the majority of pharmacists, accounting for 56.42%. Antimicrobial drug-induced ADR ranked first in our hospital, accounting for 27.24%; followed by more ADR caused by diagnostic reagents, accounting for 18.68%. ADR mainly involves the skin and its appendages, 124 cases (accounting for 48.25%), followed by the digestive system and the central nervous system. In our hospital, not only the assessed ADR is reported to the reporting staff, but also recorded in the patient’s medical record home page. Conclusion: ADR in our hospital can play a warning role in re-prescription by means of automatic alert prevention system. It not only ensures safe, reasonable and effective medication for patients, but also avoids the recurrence of ADR.