论文部分内容阅读
目的研究妊娠期肝内胆汁淤积症患者体内氧化还原系统的变化与胎儿窘迫的关系。方法选取2007年7月-2010年12月在该院产科检查发生胎儿窘迫的40例肝内胆汁淤积症孕妇作为观察组,另外选取40例未发生胎儿窘迫的肝内胆汁淤积症孕妇作为对照组,评价分析两组孕妇其他并发症及机体内氧化还原指标。结果观察组伴有妊娠期糖尿病、妊娠期贫血、妊娠期高血压疾病、早产等其他并发症人数显著大于对照组(P<0.05)。观察组孕妇丙二醛(MDA)含量(4.32±0.41μmol/L)显著高于对照组的(3.24±0.55)μmol/L,差异有统计学意义(P<0.05)。观察组超氧化物歧化酶(SOD)、一氧化氮(NO)含量均显著小于对照组(P<0.05);两组孕妇谷胱甘肽(GSH)含量比较,差异无统计学意义(P>0.05)。结论 MDA、SOD、NO及GSH参与胎儿窘迫的生理变化过程,氧化还原系统的变化对于胎儿窘迫的诊断及治疗具有重要意义。
Objective To study the relationship between redox system changes and fetal distress in patients with intrahepatic cholestasis of pregnancy. Methods From July 2007 to December 2010, 40 pregnant women with intrahepatic cholestasis who had fetal distress in obstetric examination of the hospital were selected as the observation group. Another 40 pregnant women with intrahepatic cholestasis who did not have fetal distress were selected as the control group , Evaluation and analysis of other complications of the two groups of pregnant women and body redox indicators. Results In observation group, the number of complications such as gestational diabetes mellitus, gestational anemia, gestational hypertension and premature labor were significantly higher than those in control group (P <0.05). The content of malondialdehyde (MDA) in the observation group was significantly higher than that in the control group (4.32 ± 0.41μmol / L vs 3.24 ± 0.55μmol / L, P <0.05). The levels of superoxide dismutase (SOD) and nitric oxide (NO) in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in the content of glutathione (GSH) between the two groups (P> 0.05). Conclusion MDA, SOD, NO and GSH are involved in the physiological changes of fetal distress. The changes of redox system are of great significance for the diagnosis and treatment of fetal distress.