The morphology of nanomaterials combines the characteristics of their size,shape and spatial structure.Owing to the improved spatiotemporal control of the nanocarriers for anti-cancer drug delivery,the morphology adaptive nanomaterials have received tremendous attention in the field of nanomedicine,while they are able to respond through chemical or physical change.In this review,we summarize the recent advancements of morphology adaptive nanomaterials and their application in anti-cancer drug delivery system,wherein the size,shape and spatial structure of nanocarriers can be changed to adapt the complex living system,thus overcoming the pathological barriers in drug delivery.The overview of the recent examples shows that each step of delivery process can be improved by the morphology adaption,which represents the great potential for clinic translation of morphology adaptive nanomaterials.