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目的:通过高效液相色谱法,对大鼠口服阿苯达唑(ABZ)自微乳后组织分布作初步的研究。方法:高效液相色谱法,以阿苯达唑原料药和市售片剂做对照,对口服阿苯达唑自微乳浓缩液进行大鼠体内组织分布研究,考察不同制剂体内的药物分布是否有显著性差异。结果:组织匀浆液浓度测定方法的回收率均大于70%,日内、日间精密度均小于12%;自微乳在大鼠体内分布较广,与原料药及片剂相比,各组织均有不同程度的增加,其中在体内药物浓度分布趋势为肝>肺>肠>脾>肾>胃>脑。结论:与原料药和片剂比较,ABZ-SMEDDS体内分布迅速,组织分布广泛,促进了药物口服吸收,改变了ABZ在体内的组织分布。
OBJECTIVE: To study the tissue distribution of albendazole (ABZ) self-microemulsion in rats after oral administration of high performance liquid chromatography (HPLC). Methods: High performance liquid chromatography with albendazole raw material and commercial tablets as a control, orally taken albendazole self-microemulsion concentrated tissue distribution in vivo study to see whether the different preparations in vivo drug distribution There are significant differences. Results: The recoveries of the method for determination of tissue homogenate concentration were all above 70%, the intra-day and inter-day precision was less than 12%, and the self-microemulsion was widely distributed in rats. Compared with the raw drug and tablet, There are different degrees of increase in the distribution of drug concentration trends in the body of liver> lung> intestine> spleen> kidney> stomach> brain. CONCLUSIONS: ABZ-SMEDDS is rapidly distributed in vivo and widely distributed throughout the body, promoting the oral absorption of drugs and changing the tissue distribution of ABZ in vivo.