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1973年Steinman和Cohn在研究小鼠脾脏中能粘附玻璃和塑料表面的细胞时,注意到粘附细胞中有一小群胞浆膜呈星状突起,核极不规则的细胞,并命名为树突状细胞(Dendritic cell,DC)。此后作者详细地研究了该细胞的形态、特征、分布、分离和纯化的方法,以及在体内外的生物学功能。经单克隆抗体测定,结合其独特的形态和功能,目前认为DC是一类独立的细胞群,数量很少,它积极参与免疫调节作用。其主要功能是:在MLR中是很强的刺激细胞;在T细胞对可溶性抗原反应中具有辅助效应;在移植排斥反应中是极强的MHC携带细胞。本文就现有资料对DC加以介绍。
In 1973, Steinman and Cohn observed in the mouse spleen adhesion of glass and plastic surface cells, the adherent cells noticed a small group of cytoplasm was astrias, very irregular nuclear cells, and named the tree Dendritic cells (DCs). Since then the author has studied in detail the morphology, characteristics, distribution, methods of isolation and purification, and the biological functions of the cells in vitro and in vivo. Monoclonal antibody assay, combined with its unique morphology and function, DC is currently considered an independent group of cells, a small number, it is actively involved in immune regulation. Its primary function is to strongly stimulate cells in MLR, to have an adjuvant effect on T-cell responses to soluble antigens, and to be highly MHC-carrying cells in transplant rejection. This article describes the available information on DC.