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抗毒蕈碱制剂Pirenzepine对壁细胞上的M_1受体有相对的特异作用.已有报导对十二指肠溃疡的临床治愈率为62～86%.单剂量H_2受体拮抗剂已受到极大关注.目前资料表明,夜间服用50mg Pirenzepine抑制胃液分泌20.6%而抑制酸排出量为34.1%,尚不足以有效愈合溃疡.作者选6名健康男性志愿者均为青年,受研究者服药三次,每次间隔一周.应用随机双盲法,每人接受Pirenzepine 100mg和150mg及安慰剂q.n.各3天.治疗最后一晚夜间经鼻胃管吸引胃液作分析.18点进标准晚餐.第三天的安慰剂或Pirenzepine在22
The anti-muscarinic agent Pirenzepine has a relatively specific effect on M 1 receptors on parietal cells.62-86% of the clinical cure rates have been reported for duodenal ulcers.6 Single dose H 2 receptor antagonists have been significantly impaired Concerned about the current data show that taking 50mg Pirenzepine at night to inhibit gastric secretion of 20.6% and inhibit acid output was 34.1%, not enough to effectively heal ulcers.We selected 6 healthy male volunteers were young, the researchers took three times, each One week apart, a randomized, double-blind trial of Pirenzepine 100 mg and 150 mg and placebo qn for 3 days each was performed at the end of the night, followed by nasogastric tube uptake of gastric fluid at night on the evening of 18 January, standard dinner at 18 pm, comfort on day 3 Agent or Pirenzepine at 22