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目的 探讨P选择素在肺癌转移机制中的作用。方法 采用免疫组化SP法对48例原发性肺癌组织及18例癌旁组织P选择素的表达进行检测。结果 腺癌的P选择素阳性表达率明显高于鳞癌和癌旁肺组织(P<0.01)。在腺癌中:①P选择素的阳性表达率随TNM分期的递增而逐渐增高,Ⅲ～Ⅳ期的阳性表达率明显高于Ⅰ～Ⅱ期(P<0.05);②P选择素的表达与肺癌细胞分化程度、淋巴结转移及原发肿瘤大小无明显关系(P>0.05)。结论 P选择素可能与腺癌的易浸润及血行转移有关
Objective To investigate the role of P-selectin in lung cancer metastasis. Methods Immunohistochemical SP method was used to detect the expression of P-selectin in 48 cases of primary lung cancer and 18 cases of adjacent tissues. Results The positive expression rate of P-selectin in adenocarcinoma was significantly higher than that in squamous cell carcinoma and adjacent lung tissue (P<0.01). In adenocarcinoma, the positive expression rate of 1P-selectin gradually increased with the increase of TNM stage, and the positive expression rate of stage III-IV was significantly higher than stage I-II (P<0.05); the expression of 2P-selectin and lung cancer cells There was no significant relationship between the degree of differentiation, lymph node metastasis, and primary tumor size (P>0.05). Conclusion P-selectin may be related to the infiltration and metastasis of adenocarcinoma