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目的分析河北省武安县食管癌高发区健康人群的恶性肿瘤特异性生长因子(tumor specific growth factor,TSGF)含量与有无上消化道肿瘤家族史的关系。方法从武安县医院健康体检人群中随机抽取健康人424例作为研究对象,抽取静脉血2 ml,采用生化光度定量法测定血清中TSGF含量。结果 424例健康人群的TSGF含量为38.11~93.22 U/ml,平均(57.26±6.88)U/ml;TSGF阳性57例(13.4%),阴性367例(86.6%);TSGF表达阳性组有上消化道肿瘤家族史者29例(50.9%),明显高于阴性组(123例,33.5%),差异有统计学意义(P<0.05)。结论 TSGF是一种比较敏感的肿瘤标志物,可用于健康体检及恶性肿瘤筛查。
Objective To analyze the relationship between the level of tumor specific growth factor (TSGF) and the family history of upper gastrointestinal cancer in Wu’er County, Hebei Province. Methods A total of 424 healthy subjects were randomly selected from the healthy medical examination population in Wu’an County Hospital. Two ml venous blood samples were collected and the content of TSGF in serum was determined by biochemical photometric method. Results The TSGF content of 424 healthy people was 38.11-93.22 U / ml, with an average of (57.26 ± 6.88) U / ml; 57 (13.4%) TSGF positive and 367 (86.6% The family history of tumor was found in 29 cases (50.9%), which was significantly higher than that in the negative group (123 cases, 33.5%). The difference was statistically significant (P <0.05). Conclusion TSGF is a sensitive tumor marker that can be used in health examination and malignant tumor screening.