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目的:分析抗菌药物不同时间段预防用药对剖宫产产妇术后感染的影响。方法:选取2014年3月—2016年2月间收治的需剖宫产手术的产妇210例,将其随机分为甲组、乙组和丙组,每组70例;甲组产妇在术前30 min给予头孢唑啉1 g,快速静脉滴注;乙组产妇在断脐后立即给予头孢唑啉1 g,快速静脉滴注;丙组产妇在术后给予头孢唑啉1 g,静脉滴注;比较3组产妇用药术后感染的总发生率,以及手术前后白细胞计数(WBC)及C-反应蛋白(CRP)测得值。结果:甲组和乙组产妇术后感染的发生率、WBC及CRP值明显低于丙组(P<0.05);甲组和乙组产妇术后感染的发生率、WBC及CRP测得值经比较其差异无统计学意义(P>0.05)。结论:术前30min和断脐后立即给予抗菌药物预防性使用,可降低产妇术后感染的发生率。
OBJECTIVE: To analyze the effect of prophylactic use of antibacterial drugs on postoperative infection of cesarean section in different periods of time. Methods: A total of 210 maternal women undergoing cesarean section were selected from March 2014 to February 2016. They were randomly divided into group A, group B and group C, with 70 cases in each group. Group A maternal preoperative 30 min to cefazolin 1 g, rapid intravenous infusion; B group immediately after the umbilical cord cefazolin 1 g, rapid intravenous infusion; Group C maternal postoperative cefazolin 1 g, intravenous infusion The total incidence of postoperative infection and the WBC and C-reactive protein (CRP) values before and after operation were compared between the three groups. Results: The incidences of postoperative infection and WBC and CRP in group A and group B were significantly lower than those in group C (P <0.05). The incidences of postoperative infection and WBC and CRP in group A and group B were The difference was not statistically significant (P> 0.05). CONCLUSION: Preventive administration of antimicrobial agents 30 min before and immediately after the umbilical cord can reduce the incidence of postoperative infection.