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目的观察血必净注射液治疗创伤性脓毒症患者的临床效果。方法将208例创伤性脓毒症患者随机分为研究组与对照组各104例。2组患者入院后均给予综合处理。研究组在此基础上加用血必净注射液治疗,对照组给予葡萄糖生理盐水。治疗后第5天晨空腹静脉血测血清降钙素原(PCT)、全血白细胞计数(WBC)、中性粒细胞总数(NEUT)及血小板计数(PLT)水平,并同日评估患者当日急性生理和慢性健康状况评分Ⅱ(APACHEⅡ)与序贯器官衰竭评分(SOFA),比较2组各指标差异。结果术后第5天,研究组血清PCT、WBC、NEUT水平和APACHEⅡ评分、SOFA评分明显低于对照组,PLT水平高于对照组,差异均有统计学意义(P<0.05)。结论创伤性脓毒症患者早期给予血必净治疗可明显减轻患者PCT水平,减少炎性反应,对各脏器功能具有保护作用。
Objective To observe the clinical effect of Xuebijing injection in the treatment of traumatic sepsis. Methods 208 patients with traumatic sepsis were randomly divided into study group and control group of 104 cases. Two groups of patients were given comprehensive treatment after admission. On the basis of this study, the study group was given Xuebijing injection and the control group was given glucose and saline. On the fifth day after treatment, serum procalcitonin (PCT), whole blood white blood cell count (WBC), total neutrophil count (NEUT) and platelet count (PLT) And chronic health status score (APACHE Ⅱ) and sequential organ failure score (SOFA) were compared between the two groups. Results On the 5th postoperative day, the levels of PCT, WBC, NEUT, APACHEⅡ and SOFA in the study group were significantly lower than those in the control group, and the PLT levels were higher than those in the control group (P <0.05). Conclusion Early treatment with trastuzumab in patients with traumatic sepsis can significantly reduce the level of PCT in patients, reduce the inflammatory response, and have protective effects on the function of various organs.