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选择６２０例病人，采用分级递增法进行潘生丁试验诊断冠心病，潘生丁最大剂量为２ｍｇ／ｋｇ，探讨其安全性。结果表明：敏感性随剂量增加而升高（２ｍｇ／ｋｇ时为９３．３％），特异性较强，副作用的发生率较高（７４．２％），且与用药剂量呈正相关。常见副作用有心律失常（２５．５％）、胸闷（１８．９％）、头痛（１９．１％）、心悸（１６．８％）、头胀（１３．９％），其中Ⅱ°或Ⅲ°房宣传导阻滞为３．６％，严重胸闷、大汗、恶心为０．８％。由于采用分级递增法，出现严重症状时及时停药，静推氨茶碱３～５分钟后消失，仅２例严重哮喘发作和１例严重呕吐者终止试验外，绝大多数（９９．５％）均能耐受，无１例死亡或发生急性心肌梗死，证明大剂量潘生丁试验是安全的，但已有不稳定心绞痛、急性心肌梗死、Ⅱ°或以上房宣传导阻滞、哮喘及严重阻塞性肺部疾患者不宜采用。
Select 620 patients, the use of grading ascending method for the diagnosis of coronary heart disease dipyridamole, dipyridamole maximum dose of 2mg / kg, to explore its safety. The results showed that: the sensitivity increased with dose (93.3% at 2mg / kg), strong specificity, high incidence of side effects (74.2%), and the dose was positively correlated. Common side effects include arrhythmia (25.5%), chest tightness (18.9%), headache (19.1%), palpitations (16.8%) and head swelling (13.9%), of which, ° Housing advocacy block was 3.6%, severe chest tightness, sweating, nausea at 0.8%. Due to the gradual ascending method, prompt withdrawal when severe symptoms occurred, intravenous aminophylline disappeared after 3 to 5 minutes, only 2 cases of severe asthma attack and 1 case of severe vomiting were terminated, the overwhelming majority (99.5% ) Were able to tolerate no one death or acute myocardial infarction, proved that high-dose dipyridamole test is safe, but unstable angina, acute myocardial infarction, Ⅱ ° or above atrial propaganda block, asthma and severe obstruction Patients with lung disease should not be used.