论文部分内容阅读
肿瘤细胞转移是由多种因子参与的复杂生物学行为,microRNA(miRNA)作为其中的重要因子,参与转移过程中的调控。结直肠癌患者中,转移引起的并发症是其主要死因。miRNA在结直肠癌转移中作用的研究目前尚处于起步阶段,目前已知其参与抗凋亡、上皮细胞间质化、瘤细胞增值侵袭及新生血管生成等步骤的调控,发挥促进或抑制结直肠癌细胞转移效应。本文就近年miRNA在结直肠癌的转移各通路中的作用与机制的研究进展进行综述,旨在就miRNA在临床诊断治疗的科研提供依据与思路。
Tumor cell metastasis is a complex biological behavior involving many factors. MicroRNA (miRNA) is an important factor involved in the regulation of metastasis. Colorectal cancer patients, the complications caused by metastasis is the main cause of death. The role of miRNA in the metastasis of colorectal cancer is still in its infancy, and it is known that it is involved in the regulation of anti-apoptotic, epithelial cell mesenchyme, invasion of neoplastic cells and neovascularization, and plays an important role in promoting or inhibiting colorectal Cancer metastasis effect. This review summarizes the recent progress of miRNAs in the pathways of metastasis of colorectal cancer and aims to provide the basis and train of thought for miRNAs in the research of clinical diagnosis and therapy.