目的通过对妊娠感染梅毒孕妇所分娩的婴幼儿体格生长发育情况调查,探讨妊娠梅毒对婴幼儿生长发育的影响。方法对2008年1月—2009年12月在浙江省舟山市妇幼保健院住院的妊娠梅毒孕妇分娩的43名活产婴幼儿进行体格生长发育监测和随访调查。结果梅毒感染孕妇所生婴幼儿生长发育情况与2006年WHO标准比较,各月龄的体重(42 d～18月龄)、身高(42 d男婴、出生～12月龄女婴)及头围(女婴42 d、男婴出生、42 d、6月、12月龄)差异有统计学意义(P<0.05),均高于WHO标准;与中国7岁以下儿童生长发育标准比较,各月龄的体重(男女婴42 d、女婴的9月、12月龄)、身高(男女婴42 d、男婴出生时)及头围(出生及42 d)差异有统计学意义(P<0.05),均高于平均标准值;孕期接受正规抗梅毒治疗组所生的婴幼儿各项发育指标均高于非正规治疗组,但差异无统计学意义。结论梅毒感染孕妇所生正常婴幼儿生长发育整体状况较好,但随月龄增加生长速度明显趋缓,建议建立综合防治措施,确保婴幼儿体格发育正常。 Objective To investigate the physical growth and development of infants born to pregnant women infected with syphilis in pregnancy, and to explore the impact of pregnancy syphilis on infants and young children’s growth and development. Methods The physical growth and development monitoring and follow-up survey of 43 live-born infants born to pregnant women with syphilis during pregnancy from January 2008 to December 2009 in Zhoushan Maternal and Child Health Hospital of Zhejiang Province were conducted. Results The growth and development of infants born to pregnant women with syphilis infection were compared with the WHO standard in 2006. Body weight (42 d ~ 18 months), height (42 d boys, birth ~ 12 months old baby girl) and head circumference (42 d, 42 d, 6 months, 12 months old) were significantly higher than those of the WHO (P <0.05). Compared with the standard of growth and development of children under 7 years old in China The differences of body weight (42 d for boys and girls and 9 months for 12 months for girls), height (for boys and girls for 42 days, birth of baby boy) and head circumference (for 42 days) were statistically significant (P <0.05 ) Were higher than the average standard value; during pregnancy received regular anti-syphilis treatment group infants and young children born of various indicators were higher than the non-formal treatment group, but the difference was not statistically significant. Conclusion The growth and development of normal infants born to pregnant women with syphilis infection are generally good. However, with the increase of the age, the growth rate slowed down significantly. It is suggested that comprehensive prevention and treatment measures should be established to ensure the normal physical development of infants.