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尿素乳膏可增加皮肤角质的水合作用,使皮肤柔软,且能止痒,用于防止皮肤皲裂、干燥,治疗癣屑性皮肤病,如鱼鳞癣、掌跖角化症及特应性皮炎.但尿毒乳膏的稳定性是影响其疗效的直接原因,为了提高尿素乳膏的稳定性,我们在其原处方的基础上加入甲基硅油,并对其稳定性进行留样观察.1 仪器与试剂Du-70紫外分光光度计(美国BECKMAN公司);二乙酰一肟、浓磷酸、浓硫酸、无水乙醇均为分析纯,甲基硅油、尿素为药用纯.2 实验方法2.1 试剂的配制 肟试剂:称取二乙酰一肟2g,置100ml棕色容量瓶中,加蒸馏水约90ml使溶,再加蒸馏水至刻度;酸试剂:于500ml容量瓶中,加蒸馏水约100ml,然后加浓硫酸22ml和浓磷酸33ml,摇匀,冷却至室温后用蒸馏水稀释至刻度;尿素标准液:准确称取经80℃干燥4h的尿素标准品30.0mg,置100ml容量瓶中,用无水乙醇溶解并稀释至
Urea cream can increase the skin keratin hydration, make the skin soft and can itch, used to prevent chapped skin, dry, treatment of tinea caprotic skin diseases such as ichthyosis, palmoplantar keratosis and atopic dermatitis However, the stability of uremic cream is the direct cause of its curative effect.In order to improve the stability of urea cream, we add methyl silicone oil to its original formulation, and observe the stability of the sample.An instrument And reagents Du-70 UV spectrophotometer (the United States BECKMAN company); diacetyl monoxime, concentrated phosphoric acid, concentrated sulfuric acid, ethanol were of analytical grade, methyl silicone oil, urea pure medicinal .2 Experimental 2.1 reagent Preparation of oxime reagents: weighed diacetyloxime 2g, set 100ml brown volumetric flask, add about 90ml distilled water to dissolve, add distilled water to the mark; acid reagent: in 500ml volumetric flask, add distilled water about 100ml, then add concentrated sulfuric acid 22ml and concentrated phosphoric acid 33ml, shake, cool to room temperature and dilute to the mark with distilled water; urea standard solution: accurately weighed by the 80 ℃ dried 4h urea standard 30.0mg, set 100ml volumetric flask, dissolved in anhydrous ethanol and diluted to