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本文采用冠醚法和湿热法标记了化合物~(82)Br-6-溴乙基-19-去甲胆固醇(NCL-6-Et~(82)Br),研究了这种标记物在小白鼠体内的生物分布。结果表明,它在肾上腺组织的吸收量明显高于CL-6-~(82)Br和NCL-6-~(82)Br;肾上腺/肝和肾上腺/肾比值均高于CL-6-~(82)Br,而与NCL-6-~(82)Br相近。
The compound (82) Br-6-bromoethyl-19-nor-cholesterol (NCL-6-Et ~ (82) Br) was labeled with crown ether and damp- Biodistribution in the body. The results showed that its uptake in the adrenal tissue was significantly higher than that of the CL-6- ~ (82) Br and NCL-6- ~ (82) Br; the ratio of adrenal / liver and adrenal / 82) Br, similar to NCL-6- (82) Br.