胰岛素抵抗(1R)是靶组织和靶细胞对内/外源性胰岛素(INS)的敏感性和反应性降低,即需要超常剂量的胰岛素才能维持正常生理功能的一种状态。引起1R的原因很多如先天性胰岛素基因缺陷,胰岛素受体基因突变,自身免疫性1R等,其发病率极低。本文重点探讨1R在2型糖尿病(T_2DM)发病的成因。1R是代谢综合症在共同土壤,早在 Insulin resistance (1R) is a condition in which the target tissue and target cells have reduced sensitivity and reactivity to the INS / INS, which requires an abnormally high dosage of insulin to maintain normal physiological functions. 1R caused a lot of reasons such as congenital insulin gene defects, insulin receptor gene mutations, autoimmune 1R, the incidence is extremely low. This article focuses on 1R in the pathogenesis of type 2 diabetes (T 2 DM). 1R is a metabolic syndrome in common soil, as early as in