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目的:探索米非司酮治疗子宫肌瘤的疗效。方法:68例确诊的子宫肌瘤的患者分别口服米非司酮15mg,1次/d,睡觉之前服用,连服90天为1疗程。应用彩色超声分析患者治疗前后子宫及肌瘤大小,同时对患者尿常规、血常规、黄体生成素、肝功能、卵泡刺激素、雌激素、雄激素、泌乳素、孕酮进行实验室分析。结果:在治疗期间,68例患者均出现闭经,同时临床常见症状消失,贫血状况明显改善,治疗后子宫体积平均缩小42.40%(P<0.01),子宫肌瘤平均减小49.80%(P<0.05)。与用药前相比,血液中卵泡刺激素、黄体生成素、雌激素和孕酮水平在治疗后平均水平明显下降(P<0.01)。其中以雌激素和孕酮下降最为显著,而雄激素和泌乳素用药前后没有明显变化。结论:米非司酮治疗子宫肌瘤安全、有效、经济、副作用小,值得推广使用。
Objective: To explore the efficacy of mifepristone in the treatment of uterine fibroids. Methods: 68 patients diagnosed with uterine fibroids were oral mifepristone 15mg, 1 time / d, before taking sleep, and even serving 90 days for a course of treatment. Color ultrasound was used to analyze the size of uterus and fibroids before and after treatment. Meanwhile, laboratory analysis of urine routine, blood routine, luteinizing hormone, liver function, follicle stimulating hormone, estrogen, androgen, prolactin and progesterone were performed. Results: During the treatment period, all 68 patients had amenorrhea. At the same time, the clinical symptoms disappeared and the anemia was obviously improved. After treatment, the uterine volume was reduced by 42.40% (P <0.01), and the average length of uterine fibroids was 49.80% (P <0.05) ). Compared with before treatment, blood levels of follicle stimulating hormone, luteinizing hormone, estrogen and progesterone decreased significantly after treatment (P <0.01). Estrogen and progesterone in which the most significant decline, while androgen and prolactin medication before and after no significant change. Conclusion: Mifepristone treatment of uterine fibroids safe, effective, economical, side effects, it is worth promoting the use of.