野百合碱(monocrotaline)(Ⅰ)是从草药野百合(Crotalaria sessiliflora L)分得的一种双稠吡咯啶类生物碱,含量0.3％左右,有抗肿瘤作用,局部外用治疗皮肤癌疗效可重复,但因对肝毒性大,不能全身用药,而限制了它在临床上的使用,如何使其成为理想的抗癌药,需要认识双稠吡咯啶类生物碱结构与疗效及毒性关系。对双稠吡咯啶类生物碱的结构与抗肿瘤及毒肝作用的关系有一些研究报导,但探讨结果 Monocrotaline (I) is a dipyridyl pyrrolidine alkaloid obtained from the herbaceous wild lily (Crotalaria sessiliflora L). Its content is about 0.3%, it has anti-tumor effect, and the topical treatment of skin cancer is reproducible. However, due to hepatotoxicity, it can not be used systemically, which limits its clinical use, and how to make it an ideal anticancer drug. It is necessary to understand the relationship between the structure, efficacy and toxicity of bispyrrolidine alkaloids. There are some reports on the relationship between the structure of bispyrrolidine alkaloids and their anti-tumor and hepatotoxic effects, but the results are discussed.