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已有报道莨菪类药物可用于治疗心律失常。东莨菪碱(scopolamine,Sco)可使豚鼠心室肌细胞动作电位时程(APD)与有效不应期(ERP)延长,ERP/APD比值增大。本文应用多种实验性心律失常模型,观察Sco的抗心律失常作用。
It has been reported that the treatment of arrhythmia drugs. Scopolamine (Sco) prolonged the action potential duration (APD) and effective refractory period (ERP) of guinea pig ventricular myocytes, and the ERP / APD ratio increased. In this paper, a variety of experimental arrhythmia model to observe the anti-arrhythmic effect of Sco.