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目的比较格拉司琼和恩丹西酮治疗化疗所致呕吐的经济效果。方法对40例接受顺铂化疗的患者,采用随机自身对照的方法,比较国产格拉司琼与恩丹西酮治疗化疗所致呕吐的止吐效果和毒性,并进行费用-效果分析。结果格拉司琼能有效预防顺铂所致恶心、呕吐,其止吐结果与恩丹西酮相似。两药防治恶心平均有效率分别为80.0%和78.3%;两药止吐平均有效率分别为84.2%和77.5%,疗效无统计学差异,毒副作用小。格拉司琼费用-效果比恩丹西酮优。结论盐酸格拉司琼为肿瘤化疗安全、有效、经济的止吐药物之一,值得推广应用。
Objective To compare the economic effects of granisetron and ondansetron in the treatment of chemotherapy-induced vomiting. Methods Forty patients undergoing cisplatin chemotherapy were randomized to receive self-control. The antiemetic and toxicity effects of domestic granisetron and ondansetron on vomiting induced by chemotherapy were compared and cost-effectiveness analysis was performed. Results Granisetron can effectively prevent nausea and vomiting induced by cisplatin, and its antiemetic effect is similar to that of ondansetron. The average effective rates of prevention and treatment of nausea and vomiting were 80.0% and 78.3% respectively. The average effective rates of the two drugs were 84.2% and 77.5% respectively, with no significant difference in curative effect and small toxic and side effects. Granisetron Cost-Effective Biodandrone Excellent. Conclusion Granisetron hydrochloride is one of the safe, effective and economical antiemetic drugs for cancer chemotherapy, which is worth popularizing and applying.