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目的:检测急性甲、乙型病毒性肝炎患者外周血T淋巴细胞亚群变化,探讨其对疗效和预后意义。方法:采用APAAP桥联酶标法检测115例急性甲、乙型病毒型肝炎患者外周血CD3+、CD4+、CD8+T细胞亚群比例,计算CD4+/CD8+值。并检测了34例患者治疗前后T淋巴细胞亚群变化。结果:115例急性甲、乙型病毒性肝炎患者外周血CD3+、CD4+T细胞比例及CD4+/CD8+值均低于正常对照组(P<0.05),而CD8+T细胞比例均高于正常对照组(P<0.01)。6例无明显疗效者,各亚群比例在治疗前后无显著差异(P>0.05)。28例有明显疗效者,治疗后各亚群比例恢复正常水平,与治疗前相比差别具有统计学意义(P<0.05)。结论:急性甲、乙型病毒性肝炎患者外周血CD4+/CD8+T细胞比值可在一定程度上反映疗效及预后。
Objective: To detect the changes of T lymphocyte subsets in peripheral blood of patients with acute type A and type B hepatitis B virus, and to explore its curative effect and prognostic significance. Methods: The ratio of CD3 +, CD4 + and CD8 + T cell subsets in peripheral blood of 115 patients with acute type A and type B hepatitis B virus was detected by APAPAP coupled enzyme labeling method. CD4 + / CD8 + was calculated. The changes of T lymphocyte subsets in 34 patients before and after treatment were detected. Results: The percentages of CD3 +, CD4 + T cells and CD4 + / CD8 + in peripheral blood of 115 patients with acute type A and type B hepatitis were lower than those of the normal control group (P <0.05), while the proportion of CD8 + T cells was higher than that of the normal control Group (P <0.01). Six patients had no significant effect, the proportion of each subgroup in the treatment before and after no significant difference (P> 0.05). 28 cases had significant effect, after treatment, the proportion of each subgroup returned to normal, compared with before treatment, the difference was statistically significant (P <0.05). Conclusion: The ratio of CD4 + / CD8 + T cells in peripheral blood of patients with acute type A and type B hepatitis can reflect the curative effect and prognosis to a certain extent.