论文部分内容阅读
目的:观察舒芬太尼术后镇痛对扁桃体切除术患儿的血清细胞因子IL-6、IL-10、TNF-α的变化。方法:将实行小儿扁桃体切除术后的患儿根据镇痛方法随机分成:舒芬太尼组(S组)和对照组(N组)。记录术毕、术后12、24h的BP、HR、SpO2、MAP、镇痛评分(CRIES评分)及镇痛满意率等;检测外周血IL-6、IL-10、TNF-α含量并观察并发症。结果:术后12、24h,N组CRIES的评分明显升高(P<0.05)。S组镇痛满意率明显高于N组。术后12h,S组IL-6含量均较术毕升高,N组IL-10含量较术前降低。结论:舒芬太尼可能通过抑制炎症因子改善新生儿术后的镇痛安全,并可减轻患儿手术后的炎性反应。
Objective: To observe the changes of serum cytokines IL-6, IL-10 and TNF-α in children with tonsillectomy after sufentanil postoperative analgesia. Methods: Children undergoing pediatric tonsillectomy were randomly divided into sufentanil group (group S) and control group (group N) according to the analgesic method. The levels of IL-6, IL-10 and TNF-α in peripheral blood were measured and recorded at 12 and 24 hours after operation. The levels of BP, HR, SpO2, MAP, disease. Results: At 12 and 24 hours after operation, CRIES score of N group was significantly higher (P <0.05). S group pain satisfaction rate was significantly higher than the N group. After 12 h, the content of IL-6 in group S was higher than that in group S, and the content of IL-10 in group N was lower than that in group before operation. Conclusion: Sufentanil may improve the analgesic safety of neonates by inhibiting inflammatory cytokines and relieve postoperative inflammatory reaction in children.