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近年来多项临床试验证实了他汀强化降脂治疗较之常规降脂治疗具有更显著的临床获益,并且强化降脂治疗能够延缓动脉粥样硬化斑块进展,甚至逆转斑块。现综述近年来有关他汀强化降脂更多获益及逆转斑块的证据,并进一步探讨有关“thelower,the better”的结论的临床应用及他汀逆转斑块的相关机制。
In recent years, a number of clinical trials confirmed that statin-enhanced lipid-lowering therapy has more significant clinical benefit than conventional lipid-lowering therapy, and lipid-lowering therapy can delay the progression of atherosclerotic plaque and even reverse the plaque. In this review, we summarize recent years’ evidence of further benefit of statin-lowering lipid-lowering and reversal of plaque, and further explore the clinical application of the conclusion about “the lower, the better ” and related mechanisms of statin-reversal plaque.