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再生障碍性贫血(以下简称再障)是一组红髓被脂肪髓代替,以致总容量减少血中全血细胞减少的疾病。在日本,每年发病率为1.5～2.4/10万人口,在我国河南平顶山市为1.87/10万人口。由于骨髓病变的不同,临床上可分为急、慢性型。急性型再障于短期内红髓有广泛的病变,并有非造血细胞(淋巴细胞、浆细胞、组织嗜硷细胞等)的增加,血中全血细胞减少较严重,网织红细胞多少于1%,慢性型再障骨髓呈向心性萎缩,多保留部分较好的造血组织,但巨核细胞减少。究竟再障的红髓总容量减少是加何形成的?为了说明问题,先复习正常的造血功能。
Aplastic anemia (hereinafter referred to as aplastic anemia) is a group of red pulp replaced by fatty marrow, resulting in reduced total blood pancytopenia in the disease. In Japan, the annual incidence rate is 1.5-2.4 / 100000 people, in our country Pingdingshan City, Henan Province for the 1.87 / 100000 population. Due to the different bone marrow lesions, clinically divided into acute and chronic type. Acute type of aplastic anemia in the short term has a wide range of red pulp, and non-hematopoietic cells (lymphocytes, plasma cells, tissue alkaloids, etc.) increase in blood more severe pancytopenia, reticulocyte more than 1% , Chronic aplastic anemia was centrilobular atrophy, retaining some of the more good hematopoietic tissue, but the reduction of megakaryocytes. What is the total capacity of aplastic anemia reduction is added? To illustrate the problem, first review the normal hematopoietic function.