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目的:分析2008年安徽省26例手足口病死亡病例的特征,为手足口病的防治提供科学依据。方法:对26例手足口病例和部分重症病例进行个案调查,描述流行病学和临床特征和实验室结果。结果:2008年,安徽省共报告手足口病死亡病例26例;男性15例,女性11例,男女性别比1.4∶1;年龄最小的3月龄,最大的43月龄;76.9%(20/26)病例在4月23日以前发病;病例出现发热、皮疹、呕吐、咳嗽的比例分别为96.2%、42.3%、38.5%和38.5%;核酸检测、病毒分离和病理解剖结果显示EV 71病毒阳性。结论:死亡病例均为4岁以下儿童,是由EV 71感染引起。
Objective: To analyze the characteristics of 26 deaths of hand, foot and mouth disease in Anhui province in 2008, and provide a scientific basis for the prevention and treatment of hand, foot and mouth disease. Methods: A total of 26 HFMD cases and some severe cases were investigated by case study to describe the epidemiological and clinical features and laboratory results. Results: In 2008, 26 cases of hand, foot and mouth disease were reported in Anhui Province. There were 15 males and 11 females, with a male to female ratio of 1.4:1. The youngest 3 months old, the largest 43 months old, 76.9% 26). The incidence of fever, rash, vomiting and cough were 96.2%, 42.3%, 38.5% and 38.5% respectively. The results of nucleic acid detection, virus isolation and pathological examination showed that EV71 was positive . CONCLUSIONS: All deaths were children under 4 years of age and were caused by EV 71 infection.